COULD BE A NEURODEGENERATIVE DISORDER INDICATOR A PERFECT BIOLOGICAL WEAPON ?
Just two days ago, the medical writer from the American Council on Science and Health, Steve Schow wrote the warning article about the growing danger from the prion diseases. The informative writing had a purpose to make people think more what they eat and how they get that what they eat. The prions diseases are dangerous not only for humans but also for the animals because of the zoonotic nature and the channel of transmission through the consuming the final product:meat (i.g.BSE)
It is very useful to keep in mind that prions diseases are very rare progressive neurodegenerative disorders that occur through the long incubation period and the process known as spongiform or Swiss cheese form. That could be illustrated by the rhythm of changes in the brain and spinal cord areas which stop the inflammatory response and cause in 100% of cases the fatal end.
The term prion must be understood before any further description of the prion diseases because this term is a crucial in our story. According to the CDC, prions are abnormal and pathogenic agents that are able to defect the functions of normal cellular proteins, known as prion proteins and mostly located in the brain zone. The main problem for the modern medicine is the lack of real and effective knowledge regarding the neurological issues and especially the role of prion proteins in the brain system of inputs and outputs. What science recognizes is the degenerative results of the unlimited folding of the prion proteins that indicates the severe brain damages.
How they appear to be the problem of our health nowadays?They have been known as the part of zoonotic diseases for centuries, it is enough to recall the memories on BSE, as the bovine spongiform encephalopathy that affects cattles, Chronic Wasting Disease (elk) and Scrapie disease (sheep and goats). The human version is relatively new one, since 1920s and also famous as Creutzfeldt-Jakob Disease,Variant Creutzfeldt-Jakob Disease,Gerstmann-Straussler-Scheinker Syndrome, Fatal Familial Insomnia, and Kuru. Each of them has an unique set of symptoms but only expert is capable to define the small textures of differences and to categorize them in the right way.
What i found very impressive is the fact that prions could form sporadic themselves through the years and be transferred genetically from one generation to another , something like a genetic code of curse. The above mentioned author comes out with the following:“Prions are simple proteins that occur in the brain and serve an undetermined function. They cause disease by becoming misfolded, by coming into contact with an external source of misfolded protein, as a result of a spontaneous misfolding event or as a consequence of a hereditary misfolding liability (mutations). The initial misfolded prion catalyzes the transformation of native prions into misfolded forms which cannot be cleared and begin to clump together (aggregate), eventually leading to neuronal death – death by misshapen protein. Misfolded prions are the simplest infectious agents. They differ from a toxin in that they are transmissible. Theoretically, one misfolded prion can lead to disease and death. Originally named a slow virus infection because of its decades long incubation period. It was assumed that the simplest communicable disease agent was a virus which contained either RNA or DNA as a central dogma for replication. Studies originating in the 60s and culminating in the 80s identified an aberrant protein as the causative and transmissible agent (for which a second Nobel Prize for this disease was awarded)”
Once, after the patient is diagnosed with the prion disease, the infectious prions destroy the body of the patient but they are not infectious to the others around. That is not a typical virus or bacteria that jump from one to the next host, it is more like an autoimmune destruction of the organism. The body is directed to work against itself, the similar what is happening in the process of many autoimmune diseases and even cancer. The existing protein shema is defected by the abnormal activity of the prions proteins attacked by toxic prions.
This type of disease maybe doesn’t sound so infectious and with pandemic character like very well known Ebola virus or Marburg, but the reality is latent dangerous. This is the silent but not so naive killer. The range of health demolition that prion disease bring is wide and complete. It could go in many dimensions. Take a look into the terrible events in late 80s and 90s in the beef industry of the UK, hit by BSE and the people who have been infected through the human form of the same disease. It was really disturbing to see how fast can go the infection chain from the polluted meat to the serious human diseases. The contamination was total and the consequences were beyond the imaginable. The ability to use these prions as a possible biological agents in some of the cultivated forms of attack is high and must be considered through the issue of even agro terrorist attack. If some terrorist attack some state’s meat industry, the damage is not only the ecological and medical but also the economical. The sanitation wouldn’t be so effective and no one could claim it is 100% successful as the prion disease attack is.
The advanced level of genetic research let us experiment with the prions and turn them into the living molecular sharks that will target human or animal population of the addressed subject. That is why I always suggest that the meat industry and the animal population must be replaced with the vegetarian attempts. First, it doesn’t cost so much as the livestock. Second, it is ethic and doesn’t keep us into the risk from being affected with so many diseases that naturally come from animal meat and animals at all.
The nature will be more and more aggressive with each step of the greedy mankind. We polluted the whole world . We killed so many species without any regret. Now, we are killing each others with the autoimmune diseases. Karma is the righteous and will serve us what we deserve.